Bronchopulmonary dysplasia: then and now.

Bronchopulmonary dysplasia: then and now.

Bronchopulmonary dysplasia was first described in 1967 in a series of 32 infants with severe respiratory distress syndrome who were treated with artificial ventilation and supplemental oxygen. 1 These infants had initially been given antibiotics, the usual measures for control of body temperature, and glucose and sodium bicarbonate intravenously to combat acidosis. They had not responded to thi...

Schizophrenia: Then and Now

EPS—Then and Now

"Slime" played a brief and spectacular role in the 19th century founded by the theory of primordial slime by Ernst Haeckel. However, that substance was never found and eventually abandoned. Further scientific attention slowly began in the 1930s referring to slime as a microbial product and then was inspired by "How bacteria stick" by Costerton et al. in 1978, and the matrix material was conside...

Then and Now

Fluoroquinolones: then and now.

Fluoroquinolones were discovered in the 1960s as a derivative of the antimalarial drug chloroquine. Over the past 40 years, many fluoroquinolones have been developed for use in human and veterinary medicine. As with all classes of antibiotics, resistance to fluoroquinolones is a serious concern, and multiple avenues for resistance are being investigated. Resistance-associated point mutations in...